GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| BLCA | cis | rs2294008 | 1 | rs2976392 | chr8:143762932 | PSCA | chr8:143761875-143764142:+ | 0.51 | 15.95 | 2.78E-44 | Gastric adenocarcinoma (histologically verified);Non-cardia gastric cancer;Gastric cancer;Duodenal ulcer;Bladder cancer |
| BLCA | cis | rs2294008 | 1 | rs2976394 | chr8:143763622 | LY6D | chr8:143866298-143868008:- | 0.22 | 4.79 | 2.43E-6 | Gastric adenocarcinoma (histologically verified);Non-cardia gastric cancer;Gastric cancer;Duodenal ulcer;Bladder cancer |
| BLCA | cis | rs2294008 | 1 | rs2976394 | chr8:143763622 | PSCA | chr8:143761875-143764142:+ | 0.51 | 15.95 | 2.78E-44 | Gastric adenocarcinoma (histologically verified);Non-cardia gastric cancer;Gastric cancer;Duodenal ulcer;Bladder cancer |
| BLCA | cis | rs2294008 | 1 | rs2976396 | chr8:143764001 | LY6D | chr8:143866298-143868008:- | -0.21 | -4.46 | 1.09E-5 | Gastric adenocarcinoma (histologically verified);Non-cardia gastric cancer;Gastric cancer;Duodenal ulcer;Bladder cancer |
| BLCA | cis | rs2294008 | 1 | rs2976396 | chr8:143764001 | PSCA | chr8:143761875-143764142:+ | -0.52 | -16.3 | 9.91E-46 | Gastric adenocarcinoma (histologically verified);Non-cardia gastric cancer;Gastric cancer;Duodenal ulcer;Bladder cancer |
| BLCA | cis | rs2294008 | 1 | rs2976398 | chr8:143764879 | LY6D | chr8:143866298-143868008:- | 0.22 | 4.81 | 2.21E-6 | Gastric adenocarcinoma (histologically verified);Non-cardia gastric cancer;Gastric cancer;Duodenal ulcer;Bladder cancer |
| BLCA | cis | rs2294008 | 1 | rs2976398 | chr8:143764879 | PSCA | chr8:143761875-143764142:+ | 0.52 | 16.1 | 6.5E-45 | Gastric adenocarcinoma (histologically verified);Non-cardia gastric cancer;Gastric cancer;Duodenal ulcer;Bladder cancer |
| BLCA | cis | rs2294008 | 1 | rs2978982 | chr8:143763490 | LY6D | chr8:143866298-143868008:- | 0.22 | 4.79 | 2.43E-6 | Gastric adenocarcinoma (histologically verified);Non-cardia gastric cancer;Gastric cancer;Duodenal ulcer;Bladder cancer |
| BLCA | cis | rs2294008 | 1 | rs2978982 | chr8:143763490 | PSCA | chr8:143761875-143764142:+ | 0.51 | 15.95 | 2.78E-44 | Gastric adenocarcinoma (histologically verified);Non-cardia gastric cancer;Gastric cancer;Duodenal ulcer;Bladder cancer |
| BLCA | cis | rs2985684 | 1 | rs2985696 | chr14:50094913 | RPL36AL | chr14:50085407-50087349:- | 0.23 | 4.13 | 4.51E-5 | Carotid intima media thickness |
| BLCA | cis | rs2985684 | 1 | rs2985697 | chr14:50092902 | RPL36AL | chr14:50085407-50087349:- | 0.23 | 4.28 | 2.4E-5 | Carotid intima media thickness |
| BLCA | cis | rs4660306 | 1 | rs2993259 | chr1:46001550 | CCDC163P | chr1:45960581-45965646:- | -0.78 | -15.66 | 4.56E-43 | Homocysteine levels |
| BLCA | cis | rs2985684 | 1 | rs3007030 | chr14:50086563 | RPL36AL | chr14:50085407-50087349:- | 0.23 | 4.23 | 2.99E-5 | Carotid intima media thickness |
| BLCA | cis | rs30187 | 1 | rs30187 | chr5:96124330 | ERAP1 | chr5:96096515-96149837:- | -0.51 | -10.89 | 3.07E-24 | Ankylosing spondylitis |
| BLCA | cis | rs30187 | 1 | rs30187 | chr5:96124330 | ERAP2 | chr5:96211644-96255398:+ | 0.32 | 5.31 | 1.89E-7 | Ankylosing spondylitis |